CV

Curriculum vitae
Mr. Ludwig Wiesent
München 9
94116 Hutthurm
ludwig.wiesent@bio-it.eu
+49 8505 700 8025

(date of: Feb 2017)

 

Degree:    Dipl.-Ingenieur (FH), Chemie, Biotechnologie and Bioinformatics
Year of birth:    06-05-1964
Languages:    German (mother tongue), English (fluent), Spanish (basic)
Areas of specialization:    Data and Projekt Management Pharma / Life Science
Project Lead, Tech Project Management, Project Coordinator, Head Medical compound logistics, Chem Informatics, lab logistic solutions, system architecture, embedded lab equipment (HPLC, MS, …), business analysis, drug discovery, LIMS, data visualization, Electronic Laboratory Notebook, GxP, Scientific Reporting, CSV, Quality, Validation
Certificates Qualifications:    Diploma in Bioinformatics from the University of Heidelberg
Thesis and paper:    Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B (@ Roche Bioscience, Palo Alto, USA)

portfolio

⦁    Project Management, Project Coordination in validated environment in Pharma
⦁    Very good knowledge of the technical equipment in a pharmaceutical lab (HPLC, MS, …)
⦁    High level of expertise in automation and electronic control of laboratory processes in the pharmaceutical research area
⦁    Many years of experience in networking equipment and IT systems (LIMS, ELN)
⦁    Very experienced coordinator between the interface of biology, chemistry and IT
⦁    High social competence leading relevant parties to an automated IT structure
⦁    Experience in validation of computerized systems (CSV)
⦁    Competence in improvement of system architecture (GxP)
⦁    Optimization of lab logistic solutions
⦁    Creative engineer with view of project processes and technical understanding

Knowledge and methods

⦁    GxP and CSV experience
⦁    Quality, GAMP 5, EMA Annex 11, FDA 21CFR part11
⦁    SAP ERP basic  experience
⦁    Many years of experience in dealing with different operating systems and databases in Chemistry
⦁    Competence in Integration of laboratory equipment with IT infrastructure
⦁    Development and management of a chemical compound logistics automation department (5 employees)
⦁    Coordination of complex work-flows for the cooperation of IT, technical devices and databases
⦁    High level of expertise in the management of different data from different devices and applications (HPLC, MS, HPLC-MS-MS, Thermo Orbitrap, Bar-code Reader, label printer, UV reader, alarm function, liquid handling robot
⦁    Versed in ECM, CMS and DMS
⦁    Evaluating and setting up reporting servers (JasperSoft, BIRT) and visualize data
⦁    Developing and establishing quality management for a chemical compound library
⦁    Knowledge of scripting and programming languages such as Perl, SQL, VB, .NET, C +
⦁    Many years of experience in the creation and administration of databases
⦁    Introduction of  electronic laboratory journals
⦁    Routine in dealing with virtual environments

Employment History

08/2016  – 03/2017     Vifor, Zurich /St. Gallen Switzerland
Project / Activity:     Project Manager Business
Act as global project lead and coordinator.
Review Project Plan and propose changes to the steering committee (SC)
Ensure timely execution of all project related action. Escalate resources or budget issues to SC and involved parties (stakeholders, PMs, SC)
Organize and lead project team. Document progress of the project
Ensure that system related issues are identified, tracked and resolved in a timely manner
Trigger and coordinate change control activities as needed
Interact with external vendors as required, ensure that actions are performed and issues resolved within timelines
LIMS from the headquater is rolled out to international sites. The interfaces to EDMS and different ERP Systems must be implemented coordinated. The Quality unit is the center of this activity and act in a fully CSV and GxP environment.

05/2016  – 01/2017     Merz, Frankfurt
Project / Activity:     Business Analyst
Business Analysis of existing Cheminformatics platform and reorganization existing system in the pharmaceutical department.
Make proactive suggestions of improvements of the in-house drug inventory.
Technologies:     Cheminformatics ,Drug Discovery, MySQL, Pipeline Pilot, Knime

01/2016  – 06/2016     Merck, Darmstadt
Project / Activity:     Business Analyst
Feasibility study of existing Data Management
Harmonize different existing platforms to a global LIMS – DMS and Request Management System
User Requirement Specification
Feature Specification, System Design
Evaluation of a Lab journal
Evaluation of a Request Management System
Technologies:     ORACLE, MS SQL Server, MS Access, TANGO, eWorkbook, electronical workflows, Spotfire

03/2015  – 03/2016     Bayer Healthcare, Berlin
Project / Activity:     LIMS Specialist
Implementation of LIMS „SampleManager“
Validation of LIMS and ELN System
Revision of the existing laboratory structure
Introduction of a paperless lab environment
CSV Installation of Sample Manager, ELN (Biovia)
Scientific Reporting in BIRT
Technical documentation (URS, FS, IQ, Test Cases, Risk Analysis)
Technologies:     ORACLE, GxP,     GAMP, GSOP, Risk Management, Technical Documentation, Validation, Sample Manager, ELN Biovia, BIRT, SampleManager Thermo Fischer, ELN Biovia

01/2014  – 12/2015     BioVersys, Basel
Project / Activity:     Data Manager / Cheminformatics Specialist
Analysis of the current laboratory IT structure
Revision of the existing laboratory structure
Automated loading of generated laboratory data into an existing MySQL
database
Technologies:     MySQL, VBA, SQL, INSTANT JCHEM

2013 – 2014    2Basics GmbH, Waldkirchen
Project / Activity:     SAP Consultant
Database migrations
Database account management
Individual adaptation of existing database according to customer requirements
Technologies:     SAP R3, Oracle, DB2, MSSQL Server, MaxDB, AIX, SOLARIS, Linux

2012    Agennix AG, Martinsried
Project / Activity:    Data Analyst / Developer
Analysis of the requirements for a database system for clinical trials
Create a database for recording pre-clinical data
Migration of legacy data
Individual adaptation and further development of the database according to customer requirements with advanced evaluation, search and report functions
Administration and maintenance of the database.
Technologies:    MS ACCESS 2007, VBA, ODBC, KNIME.

2011 – 2013    Proteros GmbH, Martinsried
Project / Activity:    Data Analyst / Developer
Actual and target analysis of the existing IT platform
Electronic integration of laboratory and IT landscape
Training of employees
Creating and implementing of a new concept for the data management of the entire screening group
Implementation of an electronic lab journal
Negotiations with software manufacturers
Creation and maintenance of biological databases and special tools
Implementation of a self-developed concept for compound logistics of the criteria of Lipinski (3 million chemical substances): Ordering, distribution, quality management
Technologies:    SQL, MS SQL SERVER 2008 R2, ORACLE 10, ACTIVITYBASE, VBA, PERL, ISIS BASE, CHEMFINDER, XLFIT, MATHLAB, MOSS, KNIME.

2011    U3 Pharma    (Daiichi Sankyo Company, Ltd)
Project / Activity:    Data Analyst
Analysis of the existing data structure
Installation of Microsoft Search Server Express of 2010
Installation and Administration of SharePoint Server 2010 as a DMS
Evaluation of different database management systems
Evaluation, installation, administration and development of a reporting system based on Jaspersoft (iReport, JasperServer)
Testing of various electronic lab notebooks from different manufacturers(Accelrys, Quattro). Installation of eLab (Accelry)
Technologies:    MS SEARCH SERVER, SHAREPOINT SERVER 2010, LINUX, ORACLE 9, MS SQL SERVER 2010 R2, JASPERSERVER, IREPORT

2008 – 2010    Helmholtz Center Munich
Project / Activity:    Project Manager / Team leader  Bioinformatics
Head of Bioinformatics Group (3 FTE)
Introduction, administration and development of a LIMS (Proteus, Genologics), incl. all necessary tests for adequate adaptation of the system
Implementation of LIMS “Proteus”
Tests for adequate adaptation of the system
All communication with the software manufacturer
Documentation and SOPs for laboratory staff
Introducing a virtual server architecture
Calculations for systems biology
Installation of a wiki
Technologies:    PROTEUS, ORACLE, SQL, LINUX, MATHLAB, VMWARE, ESXI, VSPHERE4, JASPERSOFT, WIKI, PIPLINEPILOT, SAMPLE MANAGER von Thermo, DOKUWIKI

2008    Kinaxo Biotechnologies GmbH, Martinsried
Project / Activity:    Data manager
Development of calculation tools for scientific data
Technologies:    VBA.

2005 – 2008    GPC Biotech AG, Martinsried
Project / Activity:    Group leader / Project Manager
Development and management of an automated compound logistics department
Development and establishment of a Quality Management System for a Small Molecule Library according to the criteria of Lipinski
Development of an in-house compound ordering system
Development of programs for liquid handling robot
Integration of technical devices in compound handling (scales, bar-code reader, Liquid pipetting robots, etc.).
Negotiating with software vendors
Development, organization and administration of the compound database
Technologies:    SQL, ORACLE, SQLBASE, WINDOWS SERVER, SQL DEVELOPER, CONFLUENCE, Activity Base, VBA, Access

2001 – 2005    Axxima Pharmaceuticals AG, Martinsried
Project / Activity:    Scientist II / Group Leader / Project Manager
Structure of the automation department for the compound logistics
Adaptation of the technical devices for reading the raw data
Implementation and administration of Activity Base (IDBS)
Construction of different databases for the chemistry and biology
Cloning and genomic assays in the department
Evaluation and visualization of genomic data
Staff training in biological and chemical software
Technologies:    ORACLE , ACTIVITYBASE (IDBS), SQL, FILEMAKER, ODBS, C+, .NET, VISUAL STUDIO.

2002    Academia Ruprecht-Karls-University Heidelberg
Education:    Bioinformatics
Certificate of the Postgraduate Program Bioinformatics
Technologies:    LIMS systems (LabView), electronic Labor journals (ChambgridgeSoft), C+, Perl, VB(A), databases, Sequence analysis, Statistics, calculating biochemical cycle

03/1999 – 03/2000    Roche Bioscience, Palo Alto, USA
Fachhochschule, Jülich, Germany
Education:    Dipl.-Ing, Fellowship and Diploma Theses
Chad D. Paavola, Stefan Hemmerich, Dorit Grunberger, Irene Polsky, Adam Bloom, Richard Freedman, Mary Mulkins, Sunhil Bhakta, Debbie McCarley, Ludwig Wiesent, Belinda Wong, Kurt Jarnagin, and Tracy M. Handel
Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B
J. Biol. Chem., Dec 1998; 273: 33157 – 33165.

References:


Dr. Ulrich Abel
Principal Scientific Expert Pharmaceutical Chemistry
Corporate Pharmaceutical Development
Merz Pharmaceuticals GmbH
Eckenheimer Landstraße 100
D-60318 Frankfurt am Main
Office: Alfred-Wegener-Straße 2
60438 Frankfurt am Main
Germany
E-Mail: ulrich.abel@merz.de

 

 

Dr. Peter C. Sennhenn
Medicinal Chemistry Bioversys, CH – Basel
peter.sennhenn@bioversys.com
sennhenn@transMedChem.com
Franz-Joseph-Straße 7
80801 München
sennhenn@transMedChem.com
www.transMedChem.com

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